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Articolo di Paul Armentano, ViceDirettore NORML.

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I ricercatori della Columbia University di New York hanno valutato l’uso di cannabinoidi rispetto al placebo in soggetti dipendenti da oppiacei sottoposti in regime di ricovero di disintossicazione e trattamento ambulatoriale con naltrexone, un antagonista dei recettori degli oppiacei.

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Gli investigatori hanno riferito che la somministrazione di THC orale (dronabinol) durante il processo di disintossicazione ha abbassato la gravità dei sintomi di astinenza nei soggetti rispetto al placebo, ma che questi effetti non persistevano a lungo termine.

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Al contrario, i pazienti che hanno consumato Cannabis durante la fase di trattamento ambulatoriale erano più facilmente in grado di dormire, hanno riferito meno ansia, e sono stati più propensi a completare il loro trattamento rispetto ai soggetti che non hanno utilizzato cannabis.

“Uno dei risultati interessanti dello studio è stato l’effetto benefico osservato nel fumare marijuana sulla conservazione del trattamento”, hanno concluso gli autori dello studio. “I partecipanti che hanno fumato marijuana avevano meno difficoltà con il sonno e l’ansia ed avevano una maggiore probabilità di rimanere in trattamento rispetto a coloro che non hanno usato la marijuana, indipendentemente dal fatto che stavano prendendo dronabinol o placebo.”

I risultati appaiono online prima della stampa sulla rivista Drug and Alcohol Dependence.

Via: Africa Studio |  Shutterstock

I risultati dello studio non sono univoci. In uno studio del 2001 pubblicato su The American Journal of droga e abuso di alcool, i ricercatori della State Psychiatric Institute di New York hanno valutato i tassi di ritenzione di trattamento tra gli 47 soggetti dipendenti da oppiacei che partecipano a un programma ambulatoriale di sei mesi. Gli autori hanno riferito che i partecipanti che hanno consumato marijuana a intermittenza avevano significativamente meno probabilità di ricominciare il loro consumo di oppiacei durante il programma, rispetto a coloro che o usavano abitualmente o astenuto dall’uso del tutto. Coloro che hanno fatto uso di cannabis nel corso del programma hanno avuto anche maggiori probabilità di aderire al trattamento con naltrexone. Gli autori hanno concluso che l’uso di marijuana occasionale è associato a migliori risultati complessivi, che “possono sostenere un approccio di riduzione del danno per la manutenzione dal naltrexone.”

Nel 2009, i ricercatori presso l’Istituto New York State Psychiatric hanno ancora valutato la relazione tra uso di cannabis e terapia oppiacea in una coorte di 63 pazienti ambulatoriali. I risultati hanno replicato quelli dello studio del 2001, scoprendo che i consumatori di cannabis intermittenti sono stati più propensi a rispettare il proprio regime di trattamento e completare il programma ambulatoriale di quelli che non hanno mai usato la sostanza.

Dati osservativi recenti dagli stati comprovano ulteriormente la teoria che l’accesso alla cannabis legale può essere un riduttore di un danno significativo per i pazienti a rischio di dipendenza da oppiacei o la mortalità.

Secondo i dati pubblicati nel 2014 nel Journal of American Medical Association, si afferma che con leggi sulla marijuana medica si sono sperimentate molte meno morti legate agli oppiacei di quanto non facciano gli Stati che vietano l’impianto. Gli investigatori della University of Pennsylvania, l’Albert Einstein College of Medicine di New York City, e il Bloomberg Scuola Johns Hopkins di sanità pubblica a Baltimora hanno condotto una analisi di serie temporali di leggi sulla cannabis medica e dati del certificato di morte a livello statale negli Stati Uniti 1999-2010 – un periodo durante il quale 13 stati hanno istituito leggi che consentono la terapia della cannabis.

Hanno riportato che, “negli Stati con leggi sulla cannabis medica si è avuto un tasso di mortalità del 24,8 per cento più basso della media annuale delle overdose da oppiacei, rispetto agli stati senza leggi sulla cannabis medica.”

Gli investigatori della RAND Corporation e l’Università della California hanno riportato risultati simili all’inizio di quest’anno in un documento programmatico per il think-tank non di parte, il National Bureau of Economic Research. “Gli Stati che permettono dispensari della marijuana medica sperimentano una diminuzione relativa in entrambe le dipendenze da oppiacei e decessi per overdose di oppiacei rispetto a Stati che non lo fanno “, hanno concluso.

Alcuni scienziati ritengono che la cannabis possa agire in sinergia con gli oppiacei. I dati clinici pubblicati nel 2011 sulla rivista Clinical Pharmacology & Therapeutics riferiscono che la somministrazione di cannabis vaporizzata “aumenta in modo sicuro l’effetto analgesico degli oppioidi.”

Gli autori hanno ipotizzato che questa “interazione sinergica” tra cannabinoidi e oppioidi “può consentire un trattamento con oppioidi a dosi più basse con meno effetti collaterali. “Di conseguenza, alcuni medici del dolore ora raccomandano che i pazienti usino la cannabis adjunctively o, in alcuni casi, prima di usare gli oppiacei come una” strategia di riduzione del danno [per] ridurre i tassi di morbilità e mortalità associati alla prescrizione dei farmaci per il dolore. ”

 

Fonte: Reset.me

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